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Ensure Effectiveness and Dependability of Formulated Medicines Using Reliable Active Pharma Ingredients and Pharmaceutical Raw Material Available Here like Escitalopram Oxalate, Dimethyl Fumarate, etc !


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Product Code : 10
Brand Name : Rolence
Price And Quantity
  • Minimum Order Quantity
  • 100 Kilograms
  • Price
  • 6000 onwards INR/Kilograms
Product Specifications
  • CAS No
  • 97240-79-4
Product Description

Topiramate is an anticonvulsant drug which is prescribed for treatment of chronic lower back pain & epilepsy. It is also most commonly indicated for preventing migraines so as to decrease frequency of attacks. This medicine shows bioavailability of about 80% with protein binding ability of up to 41%. It is consumed orally and gets rapidly absorbed after ingestion. This compound is excreted in urine after elimination half life of up to 25 hours.  Topiramate appears as white to off-white colored powder which shows solubility in methanol & dichloromethane. It has molecular formula C12H21NO8S with molar mass of 339.363 g/mol. 

IUPAC NAME - 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

Other Details:

  • Description: A White to off-white crystlline powder
  • Solubility: Freely soluble in Dichloromethane and soluble in methanol
  • Identification:
    • IR absorption:  The infrared spectrum of the test subtance should concordant with that of standard spectrum
    • HPLC test:  The retention time of the major peak in the chromatogramof the sample preparation corresponds to that of standard.
  • Melting Range:  120.0 ËšC ~130.0ËšC
  • Water Content:  NMT 0.5% W/W
  • Specific Optical Rotation at 20 Ëšc (on anhydrous basis, 0.4% in methanol):  28.0 to -35.0
  • Residue On Ignition: NMT 0.2%
  • Related Substance BY HPLC
    • Fructose: NMT 0.1%
    • Related compound A: NMT 0.1%
    • Topiramate impurity: NMT 0.1%
    • TP2 Compound: NMT 0.1%
    • Any other individual impurity: NMT 0.1%
    • Total impurities: NMT 0.5%
  • Limit of Sulphamate and Sulphate by HPLC
    • Fructose: NMT 0.1%
    • Related compound A: NMT 0.1%
  • Assay by HPLC (on anhydrous basis): 98.0% w/w ~ 102.0% w/w
    • Acetone: NMT 1500 ppm
    • Iso propyl alcohol: NMT 1500 ppm
    • Acetonitrile: NMT 300 ppm
    • Methylene chloride: NMT 250 ppm
    • n- Hexane: NMT 200 ppm
    • Ethyl acetate: NMT 2000 ppm
    • pyridine: NMT 7d ppm
    • other class 1,2,3 residual solvent and other organic solvent: Meets the requirement of other class 1,2 and 3 residual solvents as per USP 467 and no other organic solvents are present
  • Tapped Density: 0.7 g/ml ~ 1.1 g/ml
  • Partical Size (By laser diffraction) D90(Micro meters): 80.0 ~ 350.0
    • Total aerobic microbial count: NMT 1000cfu/g
    • Total combined yeasts and molds count: NMT 1000cfu/g
    • Total combined yeasts and molds count
      • Escherichia coli: Should be absent
      • Salmonella: Should be absent
      • Pseudomonas aeruginosa: Should be absent
      • Staphycoccus aures: Should be absent

Cas No 97240-79-4
Molecular Formula C12H21NO8S
Average mass 339.362 Da
Monoisotopic mass 339.098785 Da
Trade Information
  • Supply Ability
  • 1000 Kilograms Per Month
  • Delivery Time
  • 2-4 Days


Sr.No:281/1, 8-A National Highway, Ravaparnadi Road, Near Village Amar Nagar, Morbi - 363642, Gujarat, India
Phone :+918037263684
Mobile :918037263684
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