Diclofenac Sodium is widely indicated for treatment of pain, dysmenorrhea, and inflammatory disorders. It belongs to class of non-steroidal anti-inflammatory drugs and assures targeted mode of action. This compound is known to work by blocking activity of COX-2 enzyme which is responsible for synthesis of pain & inflammation causing prostaglandins. It also has antibacterial activity with ability to inhibit DNA synthesis in bacteria. Diclofenac Sodium shows more than 99% of protein binding ability with elimination half life of 1.2 to 2 hours. It gets metabolized in liver with help of CYP2C9 and CYP2C8.